After the season opener...here's a thought:

We learned in the season opener that Dean is able to vessel an angel. So since it tends to be a genetic ability, we can assume Sam also carries this "gift".

It's an unpopular thought, but what if Sam agrees to let Lucifer in because he is willing to sacrifice himself to die by Michael's sword (wielded by Dean being Michael's vessel). I know, the annoying idea of the brother fight. But really, literary symmmetry? Michael and Lucifer were brothers. And of course Sam would die when Michael kills Lucifer, but because it is the ultimate sacrifice God brings him back and we get season 6 with Sam and Dean as humans again! I know, it's crack, but I had to.

One, two, three...what might be.....

I opted to use mostly real life Jared and Jensen photos (and a few from the show) while speculating on season 5 (which starts Sept. 10) !!!

Pure speculation based lightly on spoilers for season 5 and hints from previous seasons:

---Sam and Dean will separate,
but will reunite when they finally realize they are two halves to a whole.

---Dean will use Michael's sword to kill Lucifer, but only is able to b/c of something special in his blood. This something special might be in Sam's blood too and is the answer to why he had to be the one to let Satan out.

---There will be other angels who are on humanities side than Cas and Anna.

---Meg's storyline will be finally told...I mean why is she so darn jealous?

---Somewhere, someone else said they wanted God to be a powerful black woman...I can't agree more.

---The Trickster returns and he helps the boys.

---Sam is changed permanently by what he has done, but it makes him able to defeat Lucifer.

---But by the end: Sam receives redemption.